Uolter v\u0259 Eliza Hall ad\u0131na Tibbi T\u0259dqiqatlar \u0130nstitutunun (WEHI) aliml\u0259ri a\u015fkar edibl\u0259r ki, MCL-1 z\u00fclal\u0131 x\u0259r\u00e7\u0259ng h\u00fcceyr\u0259l\u0259rini \u00f6lm\u0259kd\u0259n qoruyur, h\u0259m d\u0259 onlar\u0131 enerji il\u0259 t\u0259min edir. Ancaq onu mane\u0259 t\u00f6r\u0259d\u0259n d\u0259rmanlar \u00fcr\u0259y\u0259 v\u0259 qaraciy\u0259r\u0259, metabolik s\u00fcr\u0259ti y\u00fcks\u0259k olan orqanlara z\u0259r\u0259r verir.<\/p>\n
Ara\u015fd\u0131rman\u0131n n\u0259tic\u0259l\u0259ri \u201cScience\u201d jurnal\u0131nda d\u0259rc olunub.<\/p>\n
\u018fvv\u0259ll\u0259r MCL-1 yaln\u0131z apoptozun inhibitoru, x\u0259r\u00e7\u0259ngd\u0259 pozulan proqramla\u015fd\u0131r\u0131lm\u0131\u015f h\u00fcceyr\u0259 \u00f6l\u00fcm\u00fcn\u00fcn t\u0259bii prosesi kimi q\u0259bul edilirdi. Bununla bel\u0259, heyvan modell\u0259rind\u0259 apar\u0131lan yeni bir ara\u015fd\u0131rma ilk d\u0259f\u0259 g\u00f6st\u0259rdi ki, bu z\u00fclal olmadan h\u00fcceyr\u0259l\u0259r enerji istehsal etm\u0259k qabiliyy\u0259tini itirir, s\u00f6z\u00fcn \u0259sl m\u0259nas\u0131nda \u201cyanacaq\u201d t\u00fck\u0259nir.<\/p>\n
MCL-1 funksiyas\u0131n\u0131n yeni anlay\u0131\u015f\u0131 onkologiya \u00fc\u00e7\u00fcn x\u00fcsusil\u0259 vacibdir: z\u00fclal bir \u00e7ox aqressiv \u015fi\u015fl\u0259rin sa\u011f qalmas\u0131na k\u00f6m\u0259k edir v\u0259 onun inhibitorlar\u0131 perspektivli d\u0259rmanlar hesab olunurdu. Lakin sa\u011flam toxumalar\u0131n, x\u00fcsus\u0259n d\u0259 \u00fcr\u0259k v\u0259 qaraciy\u0259rin z\u0259d\u0259l\u0259nm\u0259si s\u0259b\u0259bind\u0259n onlar\u0131n klinik istifad\u0259si m\u0259hdud idi.<\/p>\n
Aliml\u0259r indi h\u0259yati orqanlara t\u0259sir etm\u0259d\u0259n \u015fi\u015f h\u00fcceyr\u0259l\u0259rind\u0259 MCL-1-i se\u00e7ici \u015f\u0259kild\u0259 basd\u0131racaq daha d\u0259qiq molekullar haz\u0131rlama\u011f\u0131 h\u0259d\u0259fl\u0259yirl\u0259r. Onlar art\u0131q terapiyaya daha t\u0259hl\u00fck\u0259siz yana\u015fmalar tapmaq \u00fc\u00e7\u00fcn MCL-1-i BCL-2 ail\u0259sinin dig\u0259r z\u00fclallar\u0131 il\u0259 m\u00fcqayis\u0259 etm\u0259k \u00fc\u00e7\u00fcn sistem yaratm\u0131\u015flar.<\/p>\n","protected":false},"excerpt":{"rendered":"
Uolter v\u0259 Eliza Hall ad\u0131na Tibbi T\u0259dqiqatlar \u0130nstitutunun (WEHI) aliml\u0259ri a\u015fkar edibl\u0259r ki, MCL-1 z\u00fclal\u0131 x\u0259r\u00e7\u0259ng h\u00fcceyr\u0259l\u0259rini \u00f6lm\u0259kd\u0259n qoruyur, h\u0259m d\u0259 onlar\u0131 enerji il\u0259 t\u0259min edir. Ancaq onu mane\u0259 t\u00f6r\u0259d\u0259n d\u0259rmanlar \u00fcr\u0259y\u0259 v\u0259 qaraciy\u0259r\u0259, metabolik s\u00fcr\u0259ti y\u00fcks\u0259k olan orqanlara z\u0259r\u0259r verir. Ara\u015fd\u0131rman\u0131n n\u0259tic\u0259l\u0259ri \u201cScience\u201d jurnal\u0131nda d\u0259rc olunub. \u018fvv\u0259ll\u0259r MCL-1 yaln\u0131z apoptozun inhibitoru, x\u0259r\u00e7\u0259ngd\u0259 pozulan proqramla\u015fd\u0131r\u0131lm\u0131\u015f […]<\/p>\n","protected":false},"author":3,"featured_media":73483,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36,41],"tags":[],"class_list":["post-73482","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-media","category-life"],"yoast_head":"\n