Beynin d\u0259st\u0259kl\u0259yici h\u00fcceyr\u0259l\u0259ri olan astrositl\u0259rd\u0259 istehsal olunan molekullar demans\u0131n inki\u015faf\u0131na k\u00f6m\u0259k ed\u0259 bil\u0259r. Weill Cornell Tibb M\u0259rk\u0259zinin aliml\u0259ri bel\u0259 n\u0259tic\u0259y\u0259 g\u0259libl\u0259r.<\/p>\n
T\u0259dqiqat Nature Metabolism jurnal\u0131nda d\u0259rc olunub.<\/p>\n
Aliml\u0259r diqq\u0259ti reaktiv oksigen n\u00f6vl\u0259rini (ROS) istehsal ed\u0259n h\u00fcceyr\u0259 “elektrik stansiyalar\u0131” olan mitoxondriyaya y\u00f6n\u0259ldibl\u0259r. Ki\u00e7ik miqdarda ROS beyin funksiyas\u0131n\u0131 d\u0259st\u0259kl\u0259yir, lakin onlar\u0131n h\u0259ddind\u0259n art\u0131q v\u0259 ya n\u0259zar\u0259tsiz istehsal\u0131 h\u0259yati vacib h\u00fcceyr\u0259 komponentl\u0259rin\u0259 z\u0259r\u0259r verir.<\/p>\n
Komanda z\u0259r\u0259rli ROS-nun neyronlar\u0131n mitoxondril\u0259rind\u0259 deyil, neyronlarla qar\u015f\u0131l\u0131ql\u0131 \u0259laq\u0259d\u0259 olan astrositl\u0259rd\u0259 yarand\u0131\u011f\u0131n\u0131 a\u015fkar etdi. T\u0259dqiqat\u00e7\u0131lar ROS sal\u0131nmas\u0131n\u0131 mane\u0259 t\u00f6r\u0259d\u0259n bir madd\u0259 olan S3QEL t\u0259tbiq etdikd\u0259 neyronlar qorundu. Bu t\u0259sir yaln\u0131z astrositl\u0259rin i\u015ftirak\u0131 il\u0259 m\u00fc\u015fahid\u0259 edildi, bu onlar\u0131n iltihab\u0131n v\u0259 neyronlar\u0131n z\u0259d\u0259l\u0259nm\u0259sind\u0259 \u0259sas rolunu g\u00f6st\u0259rir.<\/p>\n
ROS immun reaksiya v\u0259 metabolizmd\u0259 i\u015ftirak ed\u0259n z\u00fclallar\u0131 oksidl\u0259\u015fdirir. Bu molekullar h\u0259m\u00e7inin neyrodegenerasiya il\u0259 \u0259laq\u0259li olanlar da daxil olmaqla minl\u0259rl\u0259 genin f\u0259aliyy\u0259tini d\u0259yi\u015fdirir. S3QEL bu prosesi effektiv \u015f\u0259kild\u0259 yat\u0131r\u0131r, dig\u0259r antioksidantlar is\u0259 t\u0259sirsizdir.<\/p>\n
Frontotemporal demansl\u0131 si\u00e7anlarda S3QEL-in t\u0259tbiqi h\u0259tta x\u0259st\u0259lik simptomlar\u0131n\u0131n ba\u015flanmas\u0131ndan sonra m\u00fcalic\u0259 ba\u015flasa bel\u0259, astrositl\u0259rin aktivl\u0259\u015fm\u0259sini, neyroinflamasiyan\u0131 v\u0259 z\u0259h\u0259rli z\u00fclallar\u0131n modifikasiyas\u0131n\u0131 azald\u0131r. Qar\u0131\u015f\u0131\u011f\u0131n uzun m\u00fcdd\u0259t istifad\u0259si heyvanlar\u0131n \u00f6mr\u00fcn\u00fc d\u0259 art\u0131rd\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"
Beynin d\u0259st\u0259kl\u0259yici h\u00fcceyr\u0259l\u0259ri olan astrositl\u0259rd\u0259 istehsal olunan molekullar demans\u0131n inki\u015faf\u0131na k\u00f6m\u0259k ed\u0259 bil\u0259r. Weill Cornell Tibb M\u0259rk\u0259zinin aliml\u0259ri bel\u0259 n\u0259tic\u0259y\u0259 g\u0259libl\u0259r. T\u0259dqiqat Nature Metabolism jurnal\u0131nda d\u0259rc olunub. Aliml\u0259r diqq\u0259ti reaktiv oksigen n\u00f6vl\u0259rini (ROS) istehsal ed\u0259n h\u00fcceyr\u0259 “elektrik stansiyalar\u0131” olan mitoxondriyaya y\u00f6n\u0259ldibl\u0259r. Ki\u00e7ik miqdarda ROS beyin funksiyas\u0131n\u0131 d\u0259st\u0259kl\u0259yir, lakin onlar\u0131n h\u0259ddind\u0259n art\u0131q v\u0259 ya n\u0259zar\u0259tsiz istehsal\u0131 […]<\/p>\n","protected":false},"author":3,"featured_media":72659,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36,41],"tags":[],"class_list":["post-77267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-media","category-life"],"yoast_head":"\n